低出生体重は,同情活動の増加と関連しています:遺伝的要因への依存
Richard G IJzerman1, Coen D A Stehouwer, Eco J de Geus
1Department of Internal Medicine and Institute for Cardiovascular Research , VU University Medical Center, Amsterdam, The Netherlands.
Circulation
|July 16, 2003
まとめ
低出生体重は,成人期における高血圧と関連しており,交感神経系の活動が増加することで媒介されます. この関連性は,特に双胞胎双胞胎の双胞胎双胞胎では,遺伝的要因の影響を受けているようです.
科学分野:
- 心血管生理学 心血管の生理学
- 健康と病気の発達の起源 (DOHaD)
- 双子研究 双子研究
背景:
- 低出生体重は,後年における高血圧の潜在的な危険因子です.
- 自律神経系の活動 (交感性および寄交感性) は,この関連を媒介する可能性があります.
- 遺伝的要因も,出生体重と血圧の関係に役割を果たす可能性があります.
研究 の 目的:
- 誕生体重とシンパティックおよびパラシンパティック活動の指標との関連性を調査する.
- 青年期双子の出生体重と血圧の関係を調べる.
- 出生体重-自律的活動-血圧経路における遺伝因子の役割を調査する.
主な方法:
- 53組の二胞胎と61組の単胞胎の青少年双子を研究した.
- 測定された心前排泄期 (交感指標) と呼吸器鼻腔不律 (パラシンパティック指標).
- 休息とストレスタスク (反応時間,メンタル算数) 中の心電図とインピデンス・カルディオグラフィーを活用した.
主要な成果:
- 低出生体重は,静止状態およびストレスの高い作業の際に,より短い排泄前期と相関する.
- 双子の内部の分析では,双胞胎が二胞胎であるが,一胞胎ではない双胞胎の出産前期間の違いと関連した出生体重の違いが示された.
- 短めの出血前期は,出生体重と血圧の関連性の重要な部分 (63-84%) を説明しました.
結論:
- 低出生体重は,交感神経系の活動が増加する.
- 交感性活動の増加は,低出生体重と高血圧との関連を部分的に説明します.
- 遺伝的要因は,出生体重と交感活動の関係に影響を与えます.
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