血小板P-セレクチン発現は,ヒトの頸動脈の動脈硬化性壁の厚さに関連しています

Hidenori Koyama¹, Takaaki Maeno, Shinya Fukumoto

¹Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. hidekoyama@med.osaka-cu.ac.jp

Circulation

|July 16, 2003

まとめ

血小板P-セレクチン発現は,ヒトにおける動脈壁の厚みと硬化に関連しています. 高濃度のPセレクチンは,他の危険因子とは無関係に,頸動脈の斑塊と関連しています.

科学分野:

心血管科学の研究について
血液学ヘマトロジ
医学科学医学科学医学科学医学科学

背景:

動物モデルでは,血小板P-セレクチンが動脈硬化症の進行に影響することを示唆しています.
この研究は,ヒトにおける血小板Pセレクチンと動脈硬化症の関連性を調査しています.

研究の目的:

血小板P-セレクチン発現と動脈硬化パラメータの関係を調べる.
P-セレクチンがヒトにおける動脈硬化症の独立した予測因子であるかどうかを判断する.

主な方法:

2型糖尿病,高血圧,高脂血症などの疾患を持つ517人の被験者を登録しました.
全血流細胞測定を用いてP-セレクチン発現を測定した.
動脈の硬さとインティマ・メディアの厚さ (IMT) を,頸動脈超音波で評価した.

主要な成果:

P-セレクチン発現は,大動脈IMTと動脈硬化と正に相関しています.
P-セレクチン濃度は,頸動脈斑のある被験者においてより高く,その発生を独立して予測した.
P-セレクチンは,年齢,BMI,血圧,HbA1cと相関し,HDLコレステロールと逆相関した.

結論:

血小板P-セレクチンは,動脈硬化性動脈壁の変化と独立して関連しています.
P-セレクチンは,ヒトにおける動脈硬化症のバイオマーカーとして機能する可能性があります.

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