重要な細胞シグナル伝達と粘着タンパク質ファミリーの進化は,動物の起源より先行しています

Nicole King¹, Christopher T Hittinger, Sean B Carroll

¹Howard Hughes Medical Institute (HHMI), University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA.

Science (New York, N.Y.)

|July 19, 2003

まとめ

動物の近親であるコアノフラゲラには,重要な細胞シグナル伝達と粘着タンパク質があります. これらの発見は,これらの重要な動物性タンパク質が多細胞動物の起源より前に進化したことを示唆しています.

科学分野:

進化生物学の進化生物学について
細胞生物学細胞生物学
プロトゾオロジープロトゾオロジー

背景:

単細胞の祖先から動物の進化は,重要な細胞の革新を伴う.
チョアノフラゲル類は,メタゾアと密接に関連した単細胞およびコロニアルなプロトゾアであり,初期の動物の進化の洞察を提供します.

研究の目的:

チョアノフラゲレットの細胞シグナル伝達と粘着タンパク質の存在を調査する.
メタゾーン細胞の相互作用に関与するタンパク質の進化的起源を理解する.

主な方法:

チョアノフラゲレットにおけるタンパク質発現の分析.
タイロシン・フォスフォタンパク質のプロフィールの調査.
細胞増殖に対するチロシンキナーゼ阻害剤の効果の評価.

主要な成果:

コアノフラゲル酸は,カデリン,C型レクチン,チロシンキナーゼを含む多様な細胞シグナル伝達および粘着タンパク質ファミリーを表現します.
チョアノフラゲラートにおいて,複雑なチロシン・フォスフォタンパク質のプロファイルが観察されました.
チロシンキナーゼ阻害剤は,コアノフラゲレート細胞の増殖に影響を与えました.

結論:

メタゾアの細胞相互作用に不可欠なタンパク質は,動物が生まれる前に進化した.
これらのタンパク質は,その後,動物の発達プロセスに利用された.

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