阻害性心転写因子,SRF-Nは,ヒトの心不全におけるカスパース3分裂によって生成され,心室解荷によって弱体化されます

Jiang Chang1, Lei Wei, Takayuki Otani

  • 1Department of Molecular and Cellular Biology, Center for Cardiovascular Development, Methodist Hospital, Baylor College of Medicine, One Baylor Plaza, Houston, Tex 77030, USA.

Circulation
|July 23, 2003
PubMed
まとめ

心不全では,カスパース3が血清応答因子 (SRF) を割って,心臓遺伝子を抑制する支配的陰性因子を作り出します. このSRFの割れは,心室解荷によって逆転する可能性があります.

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