西ナイルウイルス感染症の神経学的症状と結果
James J Sejvar1, Maryam B Haddad, Bruce C Tierney
1Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, and Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Ga 30333, USA. zea3@cdc.gov
JAMA
|July 24, 2003
まとめ
西ナイルウイルス (WNV) 感染症は,運動障害や麻痺を含む重要な神経学的問題を引き起こす可能性があります. 髄膜炎や脳炎の患者はしばしば回復しますが,急性軟体性麻痺は,不可逆的な肢体の弱さにつながる可能性があります.
科学分野:
- 神経学 神経学とは
- 感染症 感染症は感染症です.
- 公衆衛生は公衆衛生である.
背景:
- 西ナイルウイルス (WNV) 感染症の神経学的症状は,将来的な特徴づけを必要とします.
- WNV患者の検査結果とアウトカムに関するデータは限られている.
研究 の 目的:
- WNV感染の臨床および研究室の特徴を将来的に文書化する.
- WNV.患者における長期的な神経学的アウトカムを評価する.
主な方法:
- 2002年8月1日から9月2日まで,ルイジアナ州セント・タマニー・パリッシュで,将来的なケースシリーズが実施されました.
- 疑わしいWNV症例について,標準化された臨床データを収集した.
- 確認されたWNV陽性患者は,8ヶ月後に再評価を受けました.
主要な成果:
- 39例の疑い症例のうち16例 (37%) はWNV陽性で,髄膜炎 (5),脳炎 (8),急性軟性麻痺 (3) を呈していた.
- 震え (94%),パーキンソン病 (69%),ミオクロノス (31%) などの運動障害が一般的であった.
- 8ヶ月で,持続的な疲労,頭痛,筋痛,歩行/運動障害が認められ,急性軟骨性麻痺の患者は四肢の強さを回復しなかった.
結論:
- WNV感染は,急性疾患の際に重要な運動障害で表れます.
- WNV髄膜炎または脳炎の患者は,長期的に有利な結果を達成することができます.
- WNVによる急性軟体性麻痺は,不可逆的なポリオomyelitisのような症候群を引き起こす可能性があります.
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