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NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
The Two-State Receptor Model01:29

The Two-State Receptor Model

The two-state receptor model explains a drug's interaction with receptors, such as G protein-coupled receptors and ligand-gated ion channels, to induce or inhibit a biological response. When no natural ligands are present, a receptor exists in an equilibrium of inactive (Ri) and active (Ra) conformations. The inactive form does not produce a response, while the active form generates a basal effect known as constitutive activity.
The binding affinity of a drug determines its interaction with one...
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Updated: May 11, 2026

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
16:10

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

Published on: March 22, 2012

TNF受容体1:分裂した人格複合体

Bryan C Barnhart1, Marcus E Peter

  • 1The Ben May Institute for Cancer Research, University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA.

Cell
|July 31, 2003
PubMed
まとめ
この要約は機械生成です。

腫瘍死滅因子受容体1 (TNFR1) 信号伝達には,アポトーシスを制御する2つの複合体が含まれる. 最初の複合体は,生存信号を活性化し,細胞死を調節するチェックポイントとして機能します.

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Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
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Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

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Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
08:48

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Published on: October 25, 2016

関連する実験動画

Last Updated: May 11, 2026

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
16:10

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

Published on: March 22, 2012

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
08:48

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Published on: October 25, 2016

科学分野:

  • 細胞生物学 細胞生物学
  • 分子シグナル伝達です.
  • アポトーシスの研究

背景:

  • 腫瘍死滅因子受容体1 (TNFR1) は,死亡受容体スーパーファミリーの主要メンバーです.
  • TNFR1シグナル伝達経路は,細胞生存とプログラム細胞死 (アポトーシス) の両方を調節することが知られている.

研究 の 目的:

  • TNFR1媒介によるアポプトティックシグナル伝達の基礎となる連続的な分子機構を解明する.
  • 細胞の運命決定を制御する際の,異なるタンパク質複合体の形成の役割を調査する.

主な方法:

  • この研究では,TNFR1の活性化後のタンパク質複合体の時間的形成を分析した.
  • 早期および遅期のシグナル伝達複合体間の機能的相互作用を調査した.

主要な成果:

  • TNFR1のアポプトティックシグナル伝達は,2つの異なる分子複合体の連続的な組み立てによって起こります.
  • 初期複合形成は,生存のための経路を活性化することができる.
  • 第2複合体の活動は第1複合体によって調節され,規制チェックポイントを確立します.

結論:

  • TNFR1シグナリングは,連続的な複雑な形成機構を通じて生存と死の経路を統合します.
  • この連続的な複雑な形成は,重要なチェックポイントとして機能し,アポトーシスの制御された実行を保証します.