代謝酵素による遺伝子スイッチング - どうやって招待リストに入れたの?
1Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Cell
|July 31, 2003
まとめ
Oct-1転写因子とOCA-S複合体は,哺乳類におけるヒストンの遺伝子発現を制御する. グリセラルデヒド-3-リン酸脱水素酶 (GADPH) は,OCA-S機能にとって驚くほど重要であり,ヒストン遺伝子転写に酸化還元依存性を加える.
科学分野:
- 分子生物学は分子生物学である.
- 遺伝子規制 遺伝子規制
- バイオケミストリー バイオケミストリー
背景:
- ヒストン遺伝子の発現は,哺乳類の細胞におけるDNA複製と修復に極めて重要です.
- Oct-1転写因子とその共同活性化剤OCA-S複合体は,ヒストン遺伝子転写のレギュレータとして知られています.
- OCA-S複合体とその調節を制御する正確な分子機構は,まだ完全に理解されていません.
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