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Updated: Jul 5, 2026

Amide Hydrogen/Deuterium Exchange & MALDI-TOF Mass Spectrometry Analysis of Pak2 Activation
07:15

Amide Hydrogen/Deuterium Exchange & MALDI-TOF Mass Spectrometry Analysis of Pak2 Activation

Published on: November 26, 2011

D-Ala-D-Lacに対するバンコミシン結合親和性の喪失を,失われたH結合と排斥的な単対の貢献に分割する

Casey C McComas1, Brendan M Crowley, Dale L Boger

  • 1Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|August 2, 2003
PubMed
まとめ

Ac2-l-Lys-d-Ala-d-Alaでアミドをメチレングループに置き換えることで,バンコマイシン結合親和性が著しく変化しました. 化合物5は1000倍減少を示し,これは主に静電相互作用によるもので,水素結合の喪失ではない.

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