心房細動を治すために肺静脈隔離は必要ですか?
Giuseppe Stabile1, Pietro Turco, Vincenzo La Rocca
1Laboratorio di Elettrofisiologia, Casa di Cura San Michele, Via Appia 178, 81024 Maddaloni, Italia. gmrstabile@tin.it
Circulation
|August 6, 2003
まとめ
肺静脈の隔離は,心房細動 (AF) の治療に不可欠ではありません. アナトミック・カテーテル・アブレーションは,患者の80%以上でAFを成功裏に予防し,純粋な解剖学的アプローチが有効であることを実証しました.
科学分野:
- 心臓病学 心臓病学
- 電気生理学 電気生理学
- 医療機器 医療機器について
背景:
- 肺静脈 (PVs) は,心房細動 (AF) の主要なトリガーおよび持続因子です.
- AF治療のためのPV電気隔離の必要性を調査することは,アブレーション戦略の精製に不可欠です.
研究 の 目的:
- 肺動脈の完全な電気隔離が,心房細動のカテーテル除去に成功するために必要かどうかを判断する.
- AF患者におけるPV骨の放射性アブレーションに対する純粋な解剖学的アプローチの有効性を評価する.
主な方法:
- パロキシズム性または持続性AFの51人の患者は,解剖学的アプローチを使用して,PVオスティアの周回放射線周波数アブレーションを受けた.
- アブラーションエンドポイントは,病変内の低バイポラーポテンシャル (<0.1mV) によって定義されました.
- 左心房のペースはPV-左心房伝導を評価し,追跡期間は平均16.6ヶ月でした.
主要な成果:
- 患者の80.4% (41/51) は,アブレーション後の心房不律症から自由でした.
- AF再発患者と非再発患者の間で,達成されたアブレーションエンドポイントやPV隔離率の有意な違いは観察されなかった.
- 完全なPV隔離は,治療に成功した患者でも,めったに示されませんでした.
結論:
- カテーテルアブレーションに対する純粋な解剖学的アプローチは,患者の80%以上でAFを予防することができます.
- 肺静脈の完全な電気隔離は,AFを治すのに不可欠ではありません.
- この研究は,電気的隔離にのみ焦点を当てることよりも,PV ostiaを解剖学的に標的にすることの有効性を強調しています.
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