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Updated: Jul 12, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Ti(IV) 媒介のエポキシ酸結合によるマクロラクトニゼーション: (-) -ダクチロリド [およびザンパノリド]の全合成

Thomas R Hoye1, Min Hu

  • 1Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA. hoye@chem.umn.edu

Journal of the American Chemical Society
|August 9, 2003
PubMed
まとめ

この研究では,ダクチロリドの全合成を詳細に説明し,新しいTi (IV) 媒介結合戦略を紹介しています. 重要なステップには,複雑な分子構造を構築するためのステレオ選択的環形成と選択的酸化が含まれます.

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Preparation of Diols and Pinacol Rearrangement

Compounds bearing two hydroxyl groups are known as diols. When the hydroxyl groups are located on adjacent carbon atoms, the diols are called vicinal diols or glycols. Under acidic conditions, vicinal diols undergo a specific reaction called pinacol rearrangement.
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Aryldiazonium Salts to Azo Dyes: Diazo Coupling

The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para position.
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Alkylation of β-Diester Enolates: Malonic Ester Synthesis

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