Ser/Thrタンパク質フォスファタゼ2B (カルシヌーリン) の高度選択的触媒部位指向阻害剤の構造ベースの設計

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Updated: Jul 19, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

Yoshiyasu Baba1, Nozomu Hirukawa, Naoto Tanohira

  • 1Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, 2-1-1 Katahira, Aoba, Sendai, Miyagi 980-8577, Japan.

Journal of the American Chemical Society
|August 9, 2003
PubMed
まとめ

研究者らは,カンタリジンを改変することによって,タンパク質フォスファターゼ2B (PP2B) の新しい選択的阻害剤を開発しました. この新しい化合物はPP2Bを直接標的とし,免疫フィリンに頼らずに細胞シグナル伝達と潜在的な治療用途の研究に貴重なツールを提供します.

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Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions06:50

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