関連する実験動画

Updated: Jun 26, 2026

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry
10:16

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

腫瘍抑制剤であるCYLDは,デウビキチネーションによってNF-kappaBのシグナリングを否定的に調節する

Andrew Kovalenko1, Christine Chable-Bessia, Giuseppina Cantarella

  • 1Department of Biological Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel.

Nature
|August 15, 2003
PubMed
まとめ

腫瘍抑制剤であるCYLDは,IKK複合体の成分をデウビキチン化することによって,NF-kappaBシグナル伝達を調節する. CYLDの変異は,この機能を損なっており,デウビキチネーションを家族性シリンドロマトーシスの病理生理学と結びつける.

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