髄膜炎症症候群における髄膜炎球菌C結合ワクチン接種後の再発リスク
A S Abeyagunawardena1, D Goldblatt, N Andrews
1Nephrourology Unit, Institute of Child Health, London, UK.
Lancet (London, England)
|August 21, 2003
まとめ
髄膜炎球菌C結合ワクチン (MCCV) は,英国の子供たちに提供されました. 腎不全症候群の患者では,MCCVが有意に再発率を増加させ,予防接種を慎重に検討する必要がある.
科学分野:
- 小児腎臓病理学について
- 免疫学 免疫学とは
- ワクチン学 ワクチン学
背景:
- 腎不全症候群は,子供に影響を与える腎臓障害である.
- 髄膜炎球菌C結合ワクチン (MCCV) は1999年に英国で18歳未満のすべての子供のために導入されました.
- 以前は,MCCVが腎不全症候群の小児に与える影響がよく知られていなかった.
研究 の 目的:
- 髄膜炎球菌C結合ワクチン (MCCV) が腎臓病症候群の小児における再発率に及ぼす影響を調査する.
主な方法:
- 腎不全症候群と診断された106人の子供のコホートが研究されました.
- 再発率は,MCCV投与前の12ヶ月と,MCCV投与後の12ヶ月で比較されました.
主要な成果:
- ワクチン接種前の12ヶ月間に合計63件の再発が記録されました.
- MCCV投与後の12ヶ月で再発数は96人に増加した.
- この再発率の増加は統計的に有意であった (p=0.009).
結論:
- 髄膜炎球菌C結合ワクチン (MCCV) の投与は,小児における腎不全症候群の再発率の有意な増加と関連していました.
- MCCVを使用した腎臓病症候群の子供に対するワクチン接種の決定は,この観察された効果のために慎重に検討する必要があります.
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