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Updated: Jul 6, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

循環型AMP応答要素結合タンパク質の阻害によって誘発されるアポプトーシス 血管の滑らかな筋肉細胞におけるアポプトーシス

Tomotake Tokunou1, Rei Shibata, Hisashi Kai

  • 1Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, 812-8582 Fukuoka, Japan.

Circulation
|August 27, 2003
PubMed
まとめ

循環型AMP応答要素結合タンパク質 (CREB) は,血管の滑らかな筋肉細胞の生存と増殖を促進し,血管の改造に影響を与えます. CREBを阻害するとアポトーシスが増加し,ネオインティマルの形成が減少し,CREBが動脈硬化疾患の治療標的であることを示唆しています.

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