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Updated: Jul 19, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

エネダイネの活性化における適合制御

M F Semmelhack1, Lingyun Wu, Robert A Pascal

  • 1Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. mfshack@princeton.edu

Journal of the American Chemical Society
|August 28, 2003
PubMed
まとめ

計算による研究では,bicyclo[7.3.1]tridec-4-ene-2,6-diyneの椅子のコンフォマーがより反応的であることが予測されました. ブリッジデリバティブの合成がこれを確認し,エネディインの毒素のサイクルアロマト化が誘発されたことを示した.

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Induced-fit Model01:13

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