csd遺伝子は蜜蜂の性発達の主な信号であり,SR型タンパク質をコードする
Martin Beye1, Martin Hasselmann, M Kim Fondrk
1Martin-Luther-Universität Halle/Wittenberg, Institut für Zoologie, Biozentrum, Weinberg Weg 22, 06120, Halle, Germany. beye@zoologie.uni-halle.de
Cell
|August 28, 2003
まとめ
ミツバチでは,補足性決定体 (CSD) の位置が性決定を制御する. 遺伝子の発現ではなく,そのアレルの変異が,個人が男性か女性として発達するかを決定する.
科学分野:
- 遺伝学 遺伝学とは
- 発達生物学 発達生物学について
- エントモロジー エントモロジー学
背景:
- 動物の20%を含むハプロディプロイド生物は,異なった性別決定を示します:不受精卵からの雄,受精卵からの雌.
- これらの種の性決定の分子メカニズムは多様で,完全に理解されていません.
研究 の 目的:
- ミツバチの補完性性決定器 (CSD) 位置における性決定の分子基礎を調査する.
- CSDが主な性決定信号としてどのように機能するのかを理解する.
主な方法:
- csd 場所の位置的なクローニング.
- 遺伝子の機能を研究するための抑制分析.
- csdアレル変動と転写レベルの分析.
主要な成果:
- csdの位置はミツバチにおける主要な性決定信号として機能し,複数のアレルは集団で分離する.
- 雄は半胞体,雌は異胞体であり,同胞体の個体は非活性の二胞体雄として発達する.
- csdアレルは高度に変化しますが,性別間の転写の違いは認められませんでした.
結論:
- 補完性性決定因子 (CSD) 位置は,そのアレル組成を通して性発育を制御し,それを主要な性決定信号として確立します.
- ディプテラスの昆虫の csd と tra 遺伝子の間の構造的な類似性は,見かけに異なった性決定システム間の潜在的な機能的な関連性を示唆しています.
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