血清アミロイドAは阻害性睡眠時無呼吸症候群に該当する.
Anna Svatikova1, Robert Wolk, Abu S Shamsuzzaman
1Mayo Foundation, Rochester, Minn, USA
Circulation
|September 4, 2003
まとめ
中程度から重度の阻害性睡眠時無呼吸症 (OSA) の患者は,血清アミロイドA (SAA) タンパク質濃度が著しく高くなっています. これらの高いSAAレベルは,OSA患者の心血管および脳血管疾患のリスクを増加させる可能性があります.
科学分野:
- 心血管医学 心血管医学
- スリープ・メディシン (睡眠医学)
- バイオケミストリー バイオケミストリー
背景:
- 阻害性睡眠時無呼吸症 (OSA) は,心血管および脳血管疾患のリスクの増加と関連しています.
- 血清アミロイドA (SAA) タンパク質は,動脈硬化症,脳卒中,糖尿病,認知症に関与しています.
- SAAレベルとOSAの関係については,さらなる調査が必要である.
研究 の 目的:
- プラズマSAA濃度がOSAを患った健康な個体において上昇しているという仮説を検証する.
- 中程度から重度のOSA,軽度のOSA,健康な対照群のSAAレベルを比較するために.
- SAAレベルとOSAの重度の間の相関を調査する.
主な方法:
- プラズマSAA濃度は,中度から重度のOSA,軽度のOSA,およびマッチングした対照群の男性および女性患者で測定されました.
- 測定は,睡眠の前に,未治療のOSAの5時間後に,および継続的な陽性気道圧 (CPAP) 治療後の朝に取られました.
- アプネア-ヒポプネア指数 (AHI) は,OSAの重症度を評価するために使用されました.
主要な成果:
- ベースラインプラズマSAA濃度は,中等度から重度のOSA患者では,対照群と比較して (18.8対7.2マイクログラム/mL,P=0.005) signicantly高かった.
- 軽度のOSA患者におけるSAA濃度は,対照群と比較した (P=0.46).
- 中度から重度のOSAにおけるSAA濃度の上昇は,男女ともに観察され,AHI (r=0.40,P=0.03) と正に相関していました.
結論:
- 血SAA濃度は,性別に関係なく,中度から重度のOSA患者の2倍以上です.
- SAAの上昇は,OSA患者の心血管および神経機能障害のリスク増加に寄与する可能性があります.
- これらの発見は,OSAに関連する合併症の潜在的なバイオマーカーとしてSAAを強調しています.
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