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Updated: Jun 23, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

薬物分子に結合したヒトのリン酸エステル酶5の触媒ドメインの構造

Byung-Je Sung1, Kwang Yeon Hwang, Young Ho Jeon

  • 1Division of Drug Discovery, CrystalGenomics, Inc., Daedeok Biocommunity, Jeonmin-dong, Yuseong-gu, Daejeon, 305-390, South Korea.

Nature
|September 5, 2003
PubMed
まとめ

研究者らは,勃起不全薬の重要な標的であるPDE5酵素の3D構造を決定した. シルデナフィル,タダラフィル,ヴァルデナフィルと複合したこれらの構造は,より効果的なPDE阻害剤の開発に役立ちます.

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