子どもや青少年における自閉症の症状領域に対する標的型治療法
Eric Hollander1, Ann T Phillips, Chin-Chin Yeh
1Seaver and New York Autism Center of Excellence, Mount Sinai School of Medicine, New York, NY 10029, USA. eric.hollander@mssm.edu
Lancet (London, England)
|September 6, 2003
まとめ
選択的セロトニン再吸収阻害剤と非典型的抗精神病薬は,自閉症スペクトル障害 (ASD) の困難な行動の管理に有望であることを示しています. 治療の利点とリスクをバランス付け,発達への影響を調査するためにさらなる研究が必要です.
科学分野:
- 神経科学は神経科学である.
- 発達心理学の心理学について
- 薬理学 薬理学とは
背景:
- 自閉症スペクトル障害 (ASD) の罹患率は増加しており,家族や医療従事者にとって大きな課題となっています.
- ASDにおける問題のある行動には,効果的な管理戦略が必要です.
- 薬理学的介入は,ASDの特定の症状領域をターゲットにすることが可能である.
研究 の 目的:
- 自閉症スペクトル障害の薬理学的治療の現状をレビューする.
- ASD介入のための臨床試験設計の進展について議論する.
- ASDにおける治療戦略の将来の方向性を特定する.
主な方法:
- ASDの薬理学的治療に関する既存の文献のレビュー.
- セロトニン再吸収抑制剤 (SSRI) と非典型抗精神病薬に関する研究の分析.
- ASDの臨床試験方法論の進歩についての議論.
主要な成果:
- 予備的なデータは,シタロプラムのようなSSRIが,ASDにおける繰り返しの行動や気分障害を減らす可能性があることを示唆しています.
- 非典型抗精神病薬であるリスペリドンは,ASDの小児における重度の行動障害の軽減に有効性を示しています.
- 改善された試験設計により,ASDにおける治療効果のより客観的な評価が可能です.
結論:
- 治療による毒性のリスクと症状の重度の利点のバランスをとることは,ASDの薬剤療法において極めて重要です.
- 患者特有の治療に関する情報に基づいた意思決定は,ますます可能になっています.
- 将来の研究は,他の症状領域,発達効果,およびASDの学前期の介入を評価する必要があります.
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