アルツハイマー・アミロイドタンパク質前駆体を過剰発現する,ミトーシス後のニューロンのインビトロ退化

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Updated: Jul 11, 2026

Imaging the Intracellular Trafficking of APP with Photoactivatable GFP
07:55

Imaging the Intracellular Trafficking of APP with Photoactivatable GFP

Published on: October 17, 2015

K Yoshikawa1, T Aizawa, Y Hayashi

  • 1Department of Molecular Biology, Tokyo Institute of Psychiatry, Japan.

Nature
|September 3, 1992
PubMed
まとめ

ニューロンにおけるβ/A4アミロイドタンパク質前駆体 (APP) の過剰発現は,神経細胞の退化につながる. 異常なAPP処理は,アルツハイマー病の病理学に寄与する可能性がある断片を生成します.

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