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Updated: Jul 16, 2026

Hydrophobic Salt-modified Nafion for Enzyme Immobilization and Stabilization
11:16

Hydrophobic Salt-modified Nafion for Enzyme Immobilization and Stabilization

Published on: July 11, 2012

Fe型ニトリルヒドラテースの新型阻害剤:2-シアノ-2-プロピル水素酸化物

Masanari Tsujimura1, Masafumi Odaka, Hiroshi Nakayama

  • 1Biomolecular Characterization Division, RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

Journal of the American Chemical Society
|September 18, 2003
PubMed
まとめ

イソブチロニトリルに含まれる新しい不純物,2-シアノ-2-プロピル水酸化物 (Cpx) は,重要なシステイン残基を酸化することによって,ニトリル水酸化物 (NHase) を不可逆的に抑制する. この酸化は酵素を無効化し, -SOH構造が触媒活性に与える重要性を強調する.

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