アプラスティック貧血とウイルス性肝炎. ノン-A, ノン-B, ノン-C?
J R Hibbs1, N Frickhofen, S J Rosenfeld
1Clinical Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Md 20892.
JAMA
|April 15, 1992
まとめ
C型肝炎ウイルスは,肝炎に関連したアプラシアと直接関連していません. 代わりに,新しい感染症剤が,このまれで致命的な症候群と fulminant 肝炎を引き起こす可能性があります.
科学分野:
- 肝臓病理学 肝臓病理学
- ウイルス学 ウイルス学 ウイルス学
- 血液学 ヘマトロジ
背景:
- 肝炎に関連したアプラスティック貧血は,まれでしばしば致命的な状態です.
- このシンドロームの原因は,ほとんど不明のままです.
研究 の 目的:
- C型肝炎ウイルス (HCV) 感染と肝炎関連アプラスティック貧血の潜在的な関連性を調査する.
- 肝炎に関連したアプラスティック貧血の根本的な原因を特定するために.
主な方法:
- 28人の肝炎関連アプラシア患者と3人の肝臓移植後の患者を含むケースシリーズ研究.
- 血清,骨髄,肝臓のサンプルにおけるポリメラーゼ連鎖反応 (PCR) を用いてHCVの検出.
- 活性化された細胞毒性Tリンパ球 (CD8+T細胞) の分析.
主要な成果:
- HCV RNAは,肝炎関連アプラシア患者の36%で検出されましたが,これは原発性感染症ではなく,発症後の輸血に関連していました.
- HCVは,NIH患者の早期サンプルや,移植を受けた患者の肝臓サンプルで検出されませんでした.
- 活性化されたCD8+Tリンパ球のレベルが上昇することは,疾患の進行初期に観察されました.
結論:
- この研究は,HCVが肝炎に関連したアプラスティック貧血の主な原因ではないことを示唆しています.
- 結果は,肝炎に関連したアプラシアと fulminant 肝炎の両方で,新しい,未確認の感染症原体を含んでいます.
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