ダイナミックな運動中に交感と免疫の相互作用. ベータ2アドレナジック依存メカニズムによるメディエーション
D R Murray1, M Irwin, C A Rearden
1Department of Medicine, University of California San Diego.
Circulation
|July 1, 1992
まとめ
急性運動はベータ2受容体を通して免疫細胞を動員し,免疫機能に影響を与えます. プロプロノロールはこれらの効果を阻害するが,メトプロロールは阻害せず,ベータ2媒介の交感神経系と免疫系との相互作用を示している.
科学分野:
- 免疫学 免疫学とは
- 神経科学は神経科学である.
- 運動生理学 運動生理学
背景:
- 交感神経系と免疫機能の相互作用は完全に理解されていません.
- 以前の研究では,カテキオラミンがβ2受容体経由でリンパ球の循環に影響することを示唆しています.
研究 の 目的:
- 急性交感刺激が免疫細胞の移動と機能にβ2受容体を通して影響するかどうかを調査する.
- 運動誘発性免疫応答におけるβ2アドレナリン受容体の役割を決定する.
主な方法:
- 健康なボランティアは,ベータブロッカー (プロプラノロールまたはメトプロロール) 治療の前と後の徹底的な運動 (ブルースプロトコル) を受けました.
- 循環するリンパ球サブセット (Ts/c,NK,Tヘルパー,B細胞) と免疫機能 (IL-2受容体発現,増殖,NK活動) を測定した.
- 非選択的β-抗原体プロプラノロールとβ-1-選択的抗原体メトプロロールの運動誘発変化に対する効果を比較した.
主要な成果:
- 激しい運動は,特にT抑制体/細胞毒性 (Ts/c) 細胞および自然キラー (NK) 細胞における顕著なリンパ球症を引き起こした.
- 運動は免疫機能を変化させ,IL-2受容体の発現と増殖を減らし,NK細胞の活動を高めます.
- プロプラノロール治療は,運動によるTs/cおよびNK細胞の増加と免疫機能の変化を鈍化させた.
- メトプロロール治療は,運動による免疫パラメータの変化には影響しませんでした.
結論:
- 運動による急性交感刺激は,選択的に免疫調節細胞を放出します.
- これらの運動によって引き起こされる免疫の変化は,β2-アドレナリン受容体によって媒介されます.
- プロプラノロルのこれらの効果の弱化は,メトプロロールとは異なり,交感性-免疫相互作用におけるβ2媒介メカニズムをサポートします.
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