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Updated: May 12, 2026

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
09:52

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

Published on: December 4, 2018

TNFは,フォスファディチルコリン特異のフォスフォリパゼC誘発"酸性"スフィンゴミエリン分解によってNF-カッパBを活性化させます

S Schütze1, K Potthoff, T Machleidt

  • 1Institut für Medizinische Mikrobiologie und Hygiene, Technische Universität München, Germany.

Cell
|November 27, 1992
PubMed
まとめ

腫瘍死滅因子 (TNF) は,フォスフォリピド経路経由で転写因子NF-kappa Bを活性化する. これはスフィンゴミエリンをセラミドに分解し,酸性スフィンゴミエリナーゼによって誘発され,最終的にNF-カッパB活性を誘発します.

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NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells10:57

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