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Updated: May 12, 2026

Inducible and Reversible Dominant-negative (DN) Protein Inhibition
08:35

Inducible and Reversible Dominant-negative (DN) Protein Inhibition

Published on: January 7, 2019

Dr1は,TATA結合タンパク質に関連したフォスフォタンパク質であり,クラスIIの遺伝子転写阻害剤である

J A Inostroza1, F H Mermelstein, I Ha

  • 1Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854-5635.

Cell
|August 7, 1992
PubMed
まとめ

研究者らは,TATA結合タンパク質 (TBP) に結合し,転写を抑制するタンパク質であるDr1を発見した. Dr1のリン酸化によって影響されるこの相互作用は,転写因子結合を阻害し,遺伝子発現の規制作用を示唆する.

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