血小板由来成長因子BBは,慢性的な圧力性潰瘍の治療のために使用されます
M C Robson1, L G Phillips, A Thomason
1Division of Plastic Surgery, University of Texas Medical Branch, Galveston 77555.
Lancet (London, England)
|January 4, 1992
まとめ
トピカル再結合ヒト血小板由来成長因子-BB (rPDGF-BB) は100マイクログラム/mlの投与で慢性圧力潰瘍の治癒を大幅に改善しました. この強力な創傷治癒剤は,フェーズI/IIの研究で有毒性効果を示さなかった.
科学分野:
- 再生医学は,再生医療である.
- 皮膚科 皮膚科について
- 創傷治癒の研究 創傷治癒の研究
背景:
- 慢性的な圧迫性潰瘍は,重要な臨床的課題を提示しています.
- 軟組織再生を促進するための効果的な治療戦略が必要である.
研究 の 目的:
- 慢性圧力潰瘍の治癒に局所的に適用される再結合ヒト血小板由来成長因子-BB (rPDGF-BB) の有効性と安全性を評価する.
- 創傷治癒のためのrPDGF-BBの最適な用量を決定する.
主な方法:
- ランダム化,I/II期,ダブルブラインド,プラセボ対照試験.
- 慢性的な圧迫性潰瘍を患った20人の患者は28日間毎日治療を受けました.
- 治療群にはプラセボと,rPDGF-BBの3つの濃度 (1, 10, 100マイクログラム/ml) が含まれていた.
主要な成果:
- 100マイクログラム/ミリリットルのrPDGF-BB群は,プラセボと比較して,著しく大きな治癒反応を示しました.
- 潰瘍の容量は,28日後に最も高いrPDGF-BB用量群では6.4%減少し,プラセボ群では21.8%減少した.
- rPDGF-BBの低用量は,傷の治癒にわずかな効果を示した. 毒性効果は観察されなかった.
結論:
- 100マイクログラム/mlの局所的なrPDGF-BBは,慢性的な圧力性潰瘍の治癒を促進する強力で安全な薬剤です.
- 軟組織創傷修復のためのrPDGF-BBのさらなる調査は正当化されています.
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