周期性乳房痛におけるゲストリノンのマルチセンター研究
1Department of Obstetrics and Gynecology, St Hildegardis Hospital, Johannes Gutenberg University, Mainz, Germany.
Lancet (London, England)
|January 25, 1992
まとめ
ゲストリノンは,プラセボと比較して,周期性マスタルジアの乳房の痛みと症状を著しく軽減しました. この研究では,ジェストリノンが循環性乳房痛の管理に効果的で,よく耐えるものであることが判明しました.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 婦人科 婦人科について
- 薬理学 薬理学とは
背景:
- 周期性マスタルジアの病因はよくわかっていない.
- エストロゲンの優位性による可能性のあるプロラクチン刺激反応の増加は,一貫した発見です.
- プロラクチンを低下させる薬や抗エストロゲンが治療に使用されます.
研究 の 目的:
- 周期性マスタルギアの治療におけるゲストリノンの有効性と安全性を調査する.
- ゲストリノンはアンドロゲン性,抗エストロゲン性,抗プロゲスゲン性を持つ.
主な方法:
- 多センター,ダブルブラインド,ランダム化研究.
- 73人の患者はゲストリノーン (2.5 mg 週2回) と72人がプラセボを3ヶ月間受けました.
- 胸の痛みと症状は,それぞれ視覚アナログスケールと0〜3スケールを用いてスコア付けされました.
主要な成果:
- ゲストリノーン群は1,2,3ヶ月で乳房痛のスコアが著しく減少した (p < 0.0001).
- 研究終了までに,ゲストリノーン群で6つの乳房症状はすべて有意に改善されました.
- ゲストリノン治療は血清のエストラジオール,プロゲステロン,トリヨドチロニンを低下させましたが,他のホルモンには影響しませんでした.
結論:
- ジェストリノンは,周期性マスタルギアの治療に非常に効果的です.
- ゲストリノンはよく耐えており,ほとんどの副作用はアンドロゲン媒介によるものです.
- プラセボと比較して,ゲストリノン群で治療を中止した患者は少なくなった.
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