自己免疫性肝疾患におけるGOR抗ウイルスとC型肝炎ウイルス

G Michel¹, A Ritter, G Gerken

¹Abbott Laboratories, European Research and Development, Wiesbaden, Germany.

Lancet (London, England)

|February 1, 1992

まとめ

Anti-GOR自己抗体は,C型肝炎ウイルス (HCV) 感染を示し,自己免疫性肝炎2型を他の肝臓疾患と区別する. この発見は慢性肝炎を区別するのに役立ち,治療的な意味を持つ.

科学分野:

免疫学免疫学とは
肝臓病理学肝臓病理学
ウイルス学ウイルス学ウイルス学

背景:

自己抗体は,自己免疫性肝疾患における重要なバイオマーカーである.
C型肝炎ウイルス (HCV) 感染は,自己免疫反応を引き起こす可能性があります.
抗GOR自己抗体は,HCV感染において観察されています.

研究の目的:

C型肝炎ウイルス (HCV) 感染症における抗GOR自己抗体の特異性を調査する.
2型自己免疫性肝炎を他の自己免疫性肝疾患とHCV感染から区別する.
慢性肝炎におけるanti-GORとLKM-1抗体の臨床的重要性を調査する.

主な方法:

抗HCV検出のための酵素関連免疫吸収測定法 (ELISA).
抗GOR,抗LKM-1,抗核,および抗溶性肝タンパク質の抗体に対する血清学的検査.
1,2,3型自己免疫性肝炎,初発性胆 ?? 硬変,全身性狼,慢性C型肝炎を含む患者グループと健康な対照群の分析.

主要な成果:

抗HCVは,自己免疫性肝炎2型患者の14/29および慢性肝炎C患者の6/6で検出されました.
Anti-GORは,11/14の抗HCV陽性自己免疫性肝炎2型患者と3/6の慢性C型肝炎患者で発見されました.
Anti-GORは,他の自己免疫性肝疾患,SLE,または健康な対照群では検出されず,HCV特異的な自己免疫性を示しました.

結論:

Anti-GOR自己抗体は,C型肝炎ウイルス (HCV) 感染症に特異的です.
HCVは,GORとLKM-1の両方のエピトープに対する自己免疫を誘発する.
抗GORとLKM-1抗体の併用検出は,慢性肝炎を区別するのに役立ち,治療的な意味合いがあります.

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