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急性および慢性的なコカイン使用が心臓に及ぼす影響
1Heart Institute Research Department, Hospital of the Good Samaritan, Los Angeles, Calif. 90017.
Circulation
|February 1, 1992
まとめ
コカインの使用は重大な心臓毒性を引き起こし,心筋動脈不全,心臓発作,心律不整を引き起こす. これらの効果を理解することは,コカインを心臓病の危険因子として認識するために不可欠です.
科学分野:
- 心臓病学 心臓病学
- 毒理学 毒理学 毒理学
- 薬理学 薬理学とは
背景:
- コカインは強力な刺激剤で,心臓に毒性があることが知られている.
- 急性および慢性的なコカイン使用は,様々な心血管異常につながる可能性があります.
- コカインの心血管リスクは,特に若い患者の場合,しばしば認識されていません.
研究 の 目的:
- コカインの心臓に有害な効果を要約すると,コカインの心臓に有害な効果を要約すると,コカインの心臓に有害な効果を要約すると,コカインの心臓に有害な効果を要約すると.
- コカイン誘発性心臓毒性の根底にあるメカニズムを解明する.
- コカインの心臓毒性に対する潜在的な治療戦略について議論する.
主な方法:
- コカインの心臓毒性に関する既存の文献のレビュー.
- コカインが心血管系に及ぼす生理学的および病理学的影響の分析.
- 提案された行動メカニズムの議論.
主要な成果:
- 急性コカイン使用は,心筋収縮を抑制し,冠動脈の血流を減らし,心拍数と血圧を上昇させ,不血症や心臓梗塞を引き起こす.
- 慢性的なコカイン使用は,動脈硬化症を加速させ,筋細胞死滅と線維症を引き起こし,心筋病に繋がり,左心室高縮を引き起こします.
- コカインによる心律乱や突然の死は,急性および慢性的なコカイン使用者において観察されています.
- メカニズムには,ナトリウムチャネル遮断とカテキオラミンの再吸収の阻害,共感出力の増加が含まれます.
結論:
- コカインは,心筋梗塞,心筋不全,心律不整など,様々な心血管疾患の重要な,しばしば認識されていない危険因子です.
- コカインの心臓毒性は,イオンチャネルとカテキオラミンレベルへの影響から生じる.
- コカインの心臓毒性に対する治療選択肢は限られ,論争の的であり,一部の薬剤は急性効果の有望性を示しています.
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