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Updated: Jun 21, 2026

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Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
全腸内栄養を摂取している子供のクロムの過剰摂取
A A Moukarzel1, M K Song, A L Buchman
1Department of Pediatrics, UCLA School of Medicine.
Lancet (London, England)
|February 15, 1992
まとめ
全腸内栄養 (TPN) を摂取している子供に推奨されるクロームの摂取量は,あまりにも高いかもしれません. 研究によると,現在のレベルは,摂取量が推奨値を下回った場合でも,腎臓機能の低下に関連しており,低クローム補給の必要性を示唆しています.
科学分野:
- 小児腎臓病理学について
- 栄養科学とは,栄養科学である.
- 臨床化学 臨床化学について
背景:
- 専門家機関は,全腸内栄養 (TPN) を受ける子供に対して,0.20マイクログラム/kg/日クロムを推奨しています.
- この推奨クロム摂取量の適切性を評価することは,小児患者の安全性にとって極めて重要です.
- 以前の研究では,TPN依存症の子供の腎機能に対するクロミウムの影響が十分に評価されていない.
研究 の 目的:
- TPNを投与している子供に対する現在の推奨クロム摂取量を評価する.
- これらの患者のクロミウム摂取量,血清クロミウム濃度,腎機能 (GFR) の間の関係を評価する.
- TPN溶液におけるクロム補給が腎臓に有害な影響を及ぼすかどうかを判断する.
主な方法:
- インジウム-111-DTPAのクリアランスを用いて,TPNを投与した15人の患者を研究し,クロミウム摂取量,血清クロミウム,およびグルメルーラ濾過率 (GFR) を測定した.
- TPN患者のGFRと血清クロミウムを,TPNでない対照群と比較した.
- クロミウム補給を中止し,1年後にGFRと血清クロミウムの変化を観察するために患者を再評価しました.
主要な成果:
- TPNを受けた子どもは,対照群と比較してGFRが著しく低下 (70 vs. 110 ml/min/1.73 m2) し,血清クロミウム濃度が20~42倍高かった.
- GFRは,血清クローム,毎日のクローム摂取量,累積摂取量,およびTPNの持続時間と有意な逆相関を示した.
- 補給を中止した後,血清クロームは減少したが,GFRは有意に変化せず,クローム欠乏症の兆候は現れなかった.
結論:
- TPNを投与している子供に推奨される親経クロミウム摂取量は過剰である可能性があります.
- 血清クロミウム濃度の上昇は,推奨摂取量以下であっても,TPN患者の腎機能障害と関連しています.
- TPN溶液におけるクローム補給量を減らすことは,潜在的な腎臓毒性を防ぐために正当化されています.
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