ストリドールと焦点喉ディストニア
1Department of Otorhinolaryngology, Fondation Rothschild, Paris, France.
Lancet (London, England)
|February 22, 1992
まとめ
喉頭ストリドールによって特徴づけられるゲルハルト症候群は,声帯誘拐器の麻痺によって引き起こされるものではありません. 代わりに,それはボツリヌム毒素注射で治療可能な焦点喉ディストニアです.
科学分野:
- 耳鼻喉科 (Otorhinolaryngology) は,耳鼻喉科 (Otorhinolaryngology) を専門とする医療機関である.
- 神経学 神経学とは
- 運動障害 運動障害
背景:
- ゲルハルト症候群は喉頭ストリドールで示され,歴史的には声帯誘拐筋の麻痺に起因する.
- この状態は,声帯の位置と呼吸道の透き通りに影響を及ぼします.
研究 の 目的:
- ゲルハルト症候群の根本的な病理生理学を調査する.
- この症候群に関連した喉頭ストリドールの治療におけるボツリヌム毒素の有効性を決定する.
主な方法:
- 繊維光学ラーリンゴスコーピーは,喉頭筋硬化症を呈する6人の患者に実施されました.
- エレクトロミオグラフィ (EMG) は,声帯の筋肉の活動を評価した.
- ボトリヌム毒素の注射は,影響を受けた患者の過活動性甲状腺筋に投与されました.
主要な成果:
- ラリンゴスコーピーは,他の局所的な原因なしにパラメディアン位置の不動の声帯を明らかにしました.
- EMGでは,声帯アドゥクターが過剰に活性化され,アドゥクター筋肉のデナーヴェーションの兆候はありませんでした.
- ボトリヌム毒素の注射は,すべての治療された患者でストレドールを成功裏に廃止しました.
結論:
- ゲルハルト症候群は,声帯誘拐器の麻痺によるものではなく,焦点性喉頭ジストニアである.
- 過剰に活発なアドクター筋を標的としたボトリヌム毒素の注射は,ゲルハルト症候群の潜在的な治療法を提供します.
- このアプローチは,アリテノイドペクシーや気管切除のような外科的介入の有効な代替案かもしれません.
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