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Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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ガン治療のための遺伝子療法

A A Gutierrez1, N R Lemoine, K Sikora

  • 1Department of Clinical Oncology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

Lancet (London, England)
|March 21, 1992
PubMed
まとめ

遺伝子転送は,腫瘍遺伝子と腫瘍抑制遺伝子をターゲットにすることで,新しいがん治療法を提供します. アンチセンセス核酸,リボ酵素,遺伝子置換などの技術は,がんを抑制し,免疫反応を強化する見込みです.

科学分野:

  • 腫瘍学 腫瘍学
  • 分子生物学は分子生物学である.
  • 遺伝子療法の遺伝子治療法

背景:

  • 癌には,腫瘍遺伝子の活性化と腫瘍抑制遺伝子の無活性化が含まれます.
  • がんにおける遺伝的イベントは,新たな治療目標を示している.
  • 遺伝子転送は,がん治療のために体細胞を改変するための潜在的な戦略を提供します.

研究 の 目的:

  • 癌治療における遺伝子移植の潜在的応用と倫理的検討を検討する.
  • 遺伝子移植ががん患者の遺伝子発現と細胞行動を調節する方法を探求する.

主な方法:

  • 現在の遺伝子転送技術と腫瘍学におけるその応用に関するレビュー.
  • 遺伝子発現調節のための情報薬 (反意味核酸,リボ酵素) についての議論.
  • 遺伝子免疫調節と標的型前薬活性化戦略の探索.

主要な成果:

  • 遺伝子転送は,腫瘍遺伝子と腫瘍抑制遺伝子発現を調節することによって,悪性行動を抑制することができます.
  • 遺伝的免疫調節は,抗腫瘍免疫反応を強化することができます.
  • 標的型遺伝子転送は,化学療法の有効性を向上させ,正常な組織を保護することができます.

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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
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Last Updated: Jun 30, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
08:32

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

結論:

  • 遺伝子移植は,重要な遺伝子変異を標的として,がん治療の有望な境界線を表しています.
  • ソマティック細胞の遺伝子転送の倫理的な意味は,慎重に検討する必要があります.
  • 将来の方向には,腫瘍抑制機能の回復のための遺伝子置換療法が含まれています.