イタリア北東部の原発性胃リンパ腫の発生率は高い
C Doglioni1, A C Wotherspoon, A Moschini
1Ospedale Civile, Feltre, Italy.
Lancet (London, England)
|April 4, 1992
まとめ
主要な胃リンパ腫 (PGL) の発生率は,英国のコミュニティと比較して,イタリアのフェルトレで13倍高い. この研究では,PGLと胃がんの割合を調査し,ヘリコバクター・ピロリ感染症の流行と関連付けました.
科学分野:
- 胃腸内科 胃腸内科
- 腫瘍学 腫瘍学
- エピデミオロジー エピデミオロジー
背景:
- 初期性胃リンパ腫 (PGL) の異常な高い発生率は,以前,イタリア北東部で観察されていました.
- 胃がんと感染症は,世界的な健康上の大きな課題となっています.
研究 の 目的:
- イタリアのフェルトレのPGLの発生率を,英国の同様のコミュニティと公式に比較する.
- 胃腺がんの発生率と,同じ地域におけるヘリコバクターパイロリ感染症の流行率を調査する.
主な方法:
- 比較疫学研究の設計. 比較疫学研究の設計.
- 1986年から1991年にかけてのPGLと胃腺がんの発生率データを分析した.
- 1991年からの胃バイオプシーサンプルにおけるヘリコバクター・パイロリ感染症の流行率の評価.
主要な成果:
- イタリアのフェルトレでは,PGLの症例が英国のコミュニティの13倍の割合で発生しました (5年間で10万人に5人に対して66人).
- 胃腺癌の発生率は,フェルトレではかなり高かった (5年間で10万人に270対82).
- H. pylori感染に関連した胃炎の流行率は,フェルトレで高かった (87%のサンプル).
結論:
- 主要な胃リンパ腫と胃腺がんの発生率は,イタリアのフェルトレで著しく上昇しています.
- ヘリコバクター・パイロリ菌の感染率が高いことは,フェルトレで観察された胃病変の増加に寄与する可能性があります.
- これらの地理的格差の背後にある病因的要因を明らかにするために,さらなる研究が必要である.
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