インスピレーションを受けた酸素濃度の上昇が慢性心不全における運動能力に与える影響
D P Moore1, A R Weston, J M Hughes
1Division of Clinical Cardiology, Royal Postgraduate Medical School, London, UK.
Lancet (London, England)
|April 4, 1992
まとめ
補充酸素は,心不全患者の運動能力を改善します. より高い酸素レベルは,運動期間を長引かせ,呼吸困難と疲労を軽減し,潜在的な治療効果を示唆します.
科学分野:
- 心臓病学 心臓病学
- 肺内医学は肺内医学である.
- 運動生理学 運動生理学
背景:
- 慢性心不全 (CHF) の患者は,限られた運動能力を経験します.
- 急性介入は,典型的には,CHFの運動耐性を改善するために無効とみなされます.
研究 の 目的:
- 安定した心不全患者の運動中の心呼吸器反応に対するインスピレーション中の酸素濃度の変動の急性効果を調査する.
- 補充酸素が急激に運動能力を改善し,CHFにおける生理学的反応を修正できるかどうかを判断する.
主な方法:
- 慢性充血性心不全の12人の患者は,連続したサブマキシマムおよびマキシマム運動テストを受けました.
- 試験は,インスピレーションを受けた酸素濃度21% (室内の空気),30%および50%で実施されました.
主要な成果:
- 平均運動時間は,室内の空気で548sから50%の酸素で632sに大幅に増加しました (p=0.012).
- 45Wの安定状態の運動で,50%の酸素で動脈の酸素飽和度が増加し,静脈換気,心拍数,疲労,呼吸困難が減少しました.
- 30%の酸素は中間的効果を示した.
結論:
- インスピレーションを受けた酸素濃度の上昇は,心不全患者の運動パフォーマンスを急激に向上させることができます.
- 高酸素症は呼吸器の反応を変化させ,酸素の供給を維持しながら,循環器の需要を減少させます.
- 慢性心不全の管理におけるインスピレーション酸素濃度の上昇の可能性については,さらなる調査が必要である.
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