ネフロティック症候群における超脂血症に対するベジタリアン大豆食の効果
G D'Amico1, M G Gentile, G Manna
1Division of Nephrology, San Carlo Hospital, Milan, Italy.
Lancet (London, England)
|May 9, 1992
まとめ
菜食的な大豆食は,腎臓病患者における高脂血症とタンパク質尿を著しく減少させた. これらの改善は,通常の食事を再開した後,ベースラインに戻り,ダイエットを示唆しました.
科学分野:
- ネフロロジーは腎臓科
- 栄養科学とは,栄養科学である.
- 心血管の健康についてです.
背景:
- 腎臓病患者はしばしば脂質異常を呈し,動脈硬化症と腎臓疾患の進行のリスクを高めます.
- 超脂血症は,慢性グローメルーラ疾患と持続的なタンパク質尿を有する患者の一般的な併発症です.
- 脂質プロファイルと腎臓症候群における腎臓のアウトカムを管理するための食事介入は調査されています.
研究 の 目的:
- 腎臓病患者における高脂血症の矯正におけるベジタリアン大豆ベースの食事の有効性を調査する.
- 慢性腎臓病患者のタンパク質尿および脂質異常に対する食事操作の影響を評価する.
主な方法:
- プロテイン尿と高脂血症の未治療腎症患者20人を対象とした制御試験.
- ベジタリアン・大豆食 (低脂肪,低タンパク質,コレステロールなし,高繊維,特定の脂肪酸プロファイル) を8週間の介入で実施.
- その後,8週間の離脱期間があり,患者は通常の食事を再開しました.
主要な成果:
- 大豆ダイエット期間中に総コレステロール,LDL,HDL,アポリポプロテインA,Bの有意な減少が観察されました.
- 血清トリグリセリド濃度は変化しなかった.
- 尿中のタンパク質の分泌は著しく低下し,洗い流す段階で基準値に戻る傾向があります.
結論:
- 菜食的な大豆食は,脂質プロフィールを効果的に改善し,腎臓病患者のタンパク質尿を減らすことができます.
- タンパク質尿に対する観察された効果は,食事中のタンパク質の改変または脂質摂取量の変化に関連している可能性があります.
- 腎機能に対するダイエットの好ましい効果の背後にある特定のメカニズムを明らかにするために,さらなる研究が必要です.
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