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Updated: Jul 21, 2026

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay
19:05

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay

Published on: October 30, 2015

MHC結合トランスポーターのポリモルフィズムが,クラスI分子に組み込まれたペプチドに与える影響

S J Powis1, E V Deverson, W J Coadwell

  • 1Department of Immunology, Agricultural and Food Research Council Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK.

Nature
|May 21, 1992
PubMed
まとめ

メジャー・ヒストコンパティビリティ・コンプレックス (MHC) にコードされたペプチドトランスポーター遺伝子の多形態化は,MHCクラスI分子に結合したペプチドのスペクトルを変化させます. この発見は,MHC構造だけでT細胞認識のためのペプチド結合を決定するという仮定に異議を唱える.

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