ニフェディピンによるニフェディピン誘発のニフェディピンによるニフェディピン誘発のニフェディピン誘発のニフェディピン誘発のニフェディピン誘発のニフェディピン誘発のニフェディピン誘発のニフェディピン誘発のニフェディピン誘発のニフェディピン
J S Ellis1, R A Seymour, S C Monkman
1Department of Operative Dentistry, Dental School, University of Newcastle upon Tyne, UK.
Lancet (London, England)
|June 6, 1992
まとめ
長期にわたってニフェディピンを使用すると,歯周腺が過剰に成長することがあります. ニフェディピンの高濃度の歯周液 (プラズマではなく) は,組織収縮がこの副作用に寄与していることを示唆しています.
科学分野:
- 薬理学 薬理学とは
- 口腔医学は,口腔医学というものです.
- バイオケミストリー バイオケミストリー
背景:
- 歯周腺の過剰成長は,ニフェディピン,サイクロスポリン,フェニトインを含む,カルシウムホメオスタシスに影響を与える特定の薬剤の既知の副作用です.
- 薬剤誘発性歯周腺過剰成長の背後にある正確なメカニズムは不明である.
研究 の 目的:
- プラズマおよび歯周膜液 (GCF) のニフェディピンの薬理 Profil farmakokinetikを調査する.
- GCFにおけるニフェディピン濃度と歯周腺過剰成長の発生との潜在的な関係を探求する.
主な方法:
- ニフェディピン濃度を測定するために超感度測定法を使用しました.
- ニフェディピンの薬理 Pharmacokinetics of nifedipineは,Angina anginaと高血圧のために長期にわたってニフェディピンを投与している9人の患者の血とGCFで分析された.
主要な成果:
- 9人の患者のうち7人は,プラズマと比較して (15〜316倍) GCFにおけるニフェディピンの最大濃度が有意に高かった.
- 検知できないGCFニフェディピン濃度を持つ2人の患者は,真の過剰成長を発症しなかった.
結論:
- 歯周腺組織はニフェディピンを隔離し,局所薬の濃度が大幅に上昇する.
- 歯周組織内のニフェディピンのこれらの高い濃度は,歯周の過剰成長を誘発する重要な要因として提案されています.
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