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Cryopreservation of Preimplantation Embryos of Cattle, Sheep, and Goats
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インビトロ受精後の累積的な受精率と生産率
S L Tan1, P Royston, S Campbell
1Hallam Medical Centre, London, UK.
Lancet (London, England)
|June 6, 1992
まとめ
イン Vitro Fertilisation (IVF) の成功率は,患者の年齢とともに低下し,不妊の原因によって異なります. 累積的な受精率と生産率は,連続した治療サイクルで低下し,IVFの結果における年齢と不妊の要因を強調しています.
科学分野:
- 生殖医学は,生殖器医学である.
- 不妊研究 不妊研究
- 助産生殖技術 (APT) とは
背景:
- 年齢と不妊の原因を考慮して,累積的な受精率と生産率を使用して,体外受精 (IVF) の成功を推定することは極めて重要ですが,データは限られています.
- 妊娠,生産,そしてIVFにおける失敗率に対する繰り返し治療サイクルの影響は,依然として不確実である.
研究 の 目的:
- 患者の年齢と不妊の原因が,IVFの結果に与える影響を評価する.
- 繰り返されたIVFサイクルの累積的な受胎率と生産率を分析する.
主な方法:
- ライフテーブルアプローチを用いた2735人の患者から5055回の連続したIVFサイクルを分析した.
- ログランクテストとロジスティック回帰を含む統計分析で,年齢と不妊症のグループ間の比率を比較します.
主要な成果:
- 1サイクルあたりの受精率と生産率は,年齢とともに著しく低下した (p < 0.001).
- 5サイクル後の累積生児率は,20〜34歳の54%,35〜39歳の28.9%,40歳以上の14.4%でした.
- 率は不妊の原因によって著しく異なる (p < 0.001),男性または多重因子不妊において最も低い. 妊娠不全率は34歳以上の女性で増加した (p = 0.006).
結論:
- 患者の年齢と不妊の原因は,IVFの成功率に影響を与える重要な要因です.
- 連続したIVF試行でサイクル毎の成功率は低下し,妊娠失敗は34歳以上の母親の年齢で増加します.
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