流行性および散発性非A,非B型肝炎の常見の病因因因子です
A Chauhan1, J B Dilawari, S Jameel
1Department of Hepatology, Post-Graduate Institute of Medical Education and Research, Chandigarh, India.
Lancet (London, England)
|June 20, 1992
まとめ
エントロウイルスのような粒子は,流行性および散発的な非A,非B (NANB) 型肝炎の原因として調査されました. これらのウイルスのような粒子 (VLP) は,患者およびサルで検出され,両方のタイプの肝炎の病因因因子であることを示唆しています.
科学分野:
- 肝臓病理学 肝臓病理学
- ウイルス学 ウイルス学 ウイルス学
- 胃腸内科 胃腸内科
背景:
- エントロウイルスのような粒子 (VLP) は,非A,非B (NANB) 型肝炎の症例で観察されています.
- 流行性および散発性NANB肝炎におけるこれらのVLPの病因学的役割は不明である.
研究 の 目的:
- エントロウイルスのような粒子が流行性および散発性NANB肝炎の病原体であるかどうかを調査する.
- 流行性および散発性NANB肝炎で発見されたVLPの特徴を比較する.
主な方法:
- 北インドで29人の流行性ウイルス性肝炎患者と9人の散発性急性ウイルス性肝炎患者を研究した.
- 診断された腸経伝染性NANB肝炎を除外.
- 血清学的クロス反応性とIgM応答を用いて,糞便と血清のサンプルにおけるウイルスのような粒子 (VLP) を検出し,特徴づけました.
- 感染したで受精したレサス猿を臨床およびウイルス学的変化を観察する.
主要な成果:
- 流行性肝炎症例の86%と散発性肝炎症例の56%が腸経伝染性NANB肝炎と診断されました.
- VLPs (30〜34nm) は,各グループから1人の患者で検出されました.
- VLPsは,急性血清サンプルで特定のIgM応答と血清学的クロス反応を示した.
- ワクチン接種されたサルでは,肝臓酵素が軽度上昇し,胆汁にVLPが含まれておりました.
結論:
- 流行性および散発性NANB肝炎の病因はおそらく同じである.
- エントロウイルスのような粒子は,腸経由で感染するNANB肝炎の病原体であると強く示唆されています.
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