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Updated: Jul 16, 2026

08:46
Single Cell Transfection in Chick Embryos
Published on: September 25, 2010
卵細胞に単一精子の細胞内注射後の妊娠
G Palermo1, H Joris, P Devroey
1Centre for Reproductive Medicine, Vrije Universiteit Brussel, Belgium.
Lancet (London, England)
|July 4, 1992
まとめ
イントラサイトプラズマ精子注射 (ICSI) は,他の方法が失敗した不妊症の症例に対する希望を提供します. このテクニックは,重度の精子問題を抱えたカップルの妊娠と健康な出産を成功させた.
科学分野:
- 生殖医学は,生殖器医学である.
- 胚学 胚学について
- 遺伝学 遺伝学とは
背景:
- イントラサイトプラズマ精子注射 (ICSI) は,高度な助産生殖技術である.
- ICSIは,イン・ビトロ受精 (IVF) またはサブゾーン内受精 (SUZI) が失敗したケースで考慮されます.
- 精子特性の深刻な障害による不妊症を治療します.
研究 の 目的:
- 男性因子不妊症のカップルにおけるICSIの有効性を評価する.
- 以前のIVF/SUZIの失敗後のICSIの成功率を評価する.
- ICSIの後に妊娠と生児の結果を記録する.
主な方法:
- ICSIは,47個のメタフェーズII卵細胞のオプラズマに単一の精子を直接注入することを含む.
- 卵細胞の生存率,受精率,胚の置換をモニタリングした.
- 治療サイクルと,その後の妊娠の結果が記録されました.
主要な成果:
- 注射された47個の卵子細胞のうち,38個が無傷のまま,31個が受精に成功しました.
- 15個の胚が子宮に移植されました.
- 8回の治療サイクルで,妊娠4回: シングレント2回,双子1回,プリクリニック中絶1回となった.
結論:
- ICSIは,IVFまたはSUZIで成功しなかった重度の男性因子不妊症のカップルのための効果的な治療法です.
- 処置の結果,生児が生まれ,シングルトン妊娠から2人の健康な男の子,双子の妊娠から1人の男の子と1人の女の子が生まれた.
- ICSIは,困難な不妊症症例において,妊娠を成功させるための大きな可能性を示しています.
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