長期チロキシン治療と骨のミネラル密度
J A Franklyn1, J Betteridge, J Daykin
1Department of Medicine, University of Birmingham, UK.
Lancet (London, England)
|July 4, 1992
まとめ
長期チロキシン置換療法は,差異性甲状腺がん患者の骨のミネラル密度に影響を与えませんでした. この研究は,チロキシン単独では,骨粗鬆症の骨折のリスクを増加させないことを示唆しています.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 骨の代謝についてです.
- 甲状腺疾患 甲状腺疾患 甲状腺疾患
背景:
- 骨のミネラル密度に対するチロキシン置換療法の効果に関して,相反する結果があります.
- いくつかの研究は,骨質の減少を示唆し,投与量削減の推奨を促しています.
研究 の 目的:
- 骨のミネラル密度に対するチロキシン療法の長期的な効果を調査する.
- タイロキシン治療が骨粗鬆症の骨折のリスクに影響を与えるかどうかを判断する.
主な方法:
- 差別化された甲状腺がんのために甲状腺切除術後の49人の患者のコホートは,長期のチロキシン療法を受けた.
- 患者は年齢,性別,BMI,ライフスタイル要因に基づいて対照群とマッチングした.
- 骨のミネラル密度は,複数の骨格部位で二重エネルギーX線吸収測定法を使用して測定されました.
主要な成果:
- 長期チロキシン療法を受けた患者と対照群の間では,骨のミネラル密度の有意な違いは観察されなかった.
- 骨のミネラル密度は,チロキシン用量,治療期間,または甲状腺機能検査と相関しませんでした.
- 両グループとも,年齢に関係した骨密度の低下を示した.
結論:
- 異なる甲状腺がん治療の文脈で,チロキシン置換療法は,骨のミネラル密度に悪影響を及ぼさないようです.
- タイロキシン単独では,骨粗鬆症の骨折の重要な危険因子である可能性は低い.
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