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生物化学的コレスタシスによる季節性暗号原性肺炎:新しい臨床実体
M A Spiteri1, P Klenerman, M N Sheppard
1Royal Brompton Hospital, London, UK.
Lancet (London, England)
|August 1, 1992
まとめ
この研究は,肝臓酵素異常を伴う季節性組織性肺炎症候群を特定しています. 症状は毎年再発し,環境からの吸入によるトリガーを示唆し,ステロイド療法に反応する.
科学分野:
- 肺病理学 肺病理学とは
- 肝臓病理学 肝臓病理学
- 環境医学 環境医学
背景:
- 暗号性組織性肺炎 (COP) は,特定の臨床,放射線,および組織学的発見によって特徴付けられます.
- COPの季節的な再発は,以前は十分に文書化されていない.
- COPにおける関連性肝内コレスタシスはまれである.
研究 の 目的:
- 同時期に肝内コレスタシスを伴う肺炎を組織する独特の季節性症候群を記述する.
- この季節性障害の患者の臨床的特徴,進行および治療への反応を調査する.
- この再発性呼吸器系および肝臓疾患の潜在的な環境トリガーを調査する.
主な方法:
- 組織性肺炎の季節的な再発が記録された12人の患者の遡及的症例シリーズ.
- 症状日記,胸部X線写真,コンピュータトモグラフィー (CT),肺機能検査を含む臨床評価.
- 肺生検のサンプルを組織病理学的に検査する.
- 肝機能の生化学的評価と感染症原体の排除.
主要な成果:
- 全12人の患者は3~11年以上にわたり,年間症状の再発 (2月下旬~5月上旬) と解消 (6月~1月) を示した.
- 胸部イメージングは双方の統合を明らかにし,肺生検は膜内粒子の組織と呼吸道阻害を示した.
- 肺機能は主に制限的であり,すべての患者は肝臓内コレスタシスを示唆する肝臓酵素値が上昇していた.
- 感染症検査とウイルス検診は陰性であり,すべての患者は経口ステロイドに迅速に反応した.
結論:
- 肝内コレスタシスによる組織性肺炎の独特の季節性症候群が特定されています.
- 年間周期性は,特定の季節に特異的な吸入された環境汚染物質を強く示唆しています.
- この再発性疾患の原因となる特定の病原体を特定するために,さらなる研究が必要である.
関連する概念動画
COPD: Pathogenesis and Clinical Features
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Pneumonia I: Introduction
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Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
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Atypical Pneumonia
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Chronic Obstructive Pulmonary Disease II: Emphysema
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Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
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Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...

