安定した冠動脈動脈疾患における運動誘発性発血症に対するリボースの効果
W Pliml1, T von Arnim, A Stäblein
1Department of Medicine, Medizinische Klinik I, Klinikum Grosshadern, Germany.
Lancet (London, England)
|August 29, 1992
まとめ
リボースのサプリメントは,冠動脈疾患 (CAD) の患者の心不全耐性を改善しました. このペントース糖は,心筋のエネルギー代謝を高め,心臓病の潜在的補助治療を提供しました.
科学分野:
- 心臓病学 心臓病学
- バイオケミストリー バイオケミストリー
- メタボリック医学は
背景:
- 心臓のエネルギー代謝はイシュケミアによって損なわれ,ATPの低いレベルは再注射後も持続する.
- 低ATP含有量は,長期にわたる後発血性機能不全と不可逆的な損傷と関連しています.
- 発血中の心臓のエネルギー代謝を保護または回復するための確立された治療法は存在しない.
研究 の 目的:
- リボースのサプリメントが冠動脈動脈疾患 (CAD) の患者における心筋不全症の耐性を高めるかどうかを調査する.
- リボースが心臓のATP合成と性不全状態でのエネルギー代謝に及ぼす影響を評価する.
主な方法:
- 20人の重度のCADの男性を対象としたランダム化,プラセボ対照試験です.
- 患者は3日間,毎日プラセボまたは60gのリボースを投与されました.
- 症状を制限したトレッドミルの運動テストは,治療前のおよび治療後の間で,イシュケミアの耐性を評価するために実施されました.
主要な成果:
- リボース治療は,プラセボと比較して,トレッドミルの歩行時間を1mmのSTセグメントうつまで大幅に増加させました (276s vs 223s,p=0.002).
- STうつ病と胸痛までの時間の有意な改善は,ベースラインから第5日までのリボース群では観察されたが,プラセボ群では観察されなかった.
- グループ間でアンギナが軽度になるまでの間に有意な差は認められませんでした.
結論:
- 3日間の経口リボース投与は,CADの患者における心筋動脈不全症の耐性を高めます.
- 心臓のエネルギー代謝に対する推定された影響は,リボースを心筋小動脈不全の潜在的な補助療法として示唆しています.
- リボースは,心臓のエネルギー代謝の障害を含む状態の管理のための新しい治療的道を提供することができます.
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