非ヒトの霊長類におけるフィロウイルスクリアランス
S P Fisher-Hoch1, G I Perez-Oronoz, E L Jackson
1Special Pathogens Branch, Centers for Disease Control, Atlanta, Georgia 30333.
Lancet (London, England)
|August 22, 1992
まとめ
低フィロウイルス抗体位を持つ健康なサルは,感染しません. 研究では,フィロウイルス感染後の霊長類におけるウイルスのクリアランスと抗体の発生が示されており,ヒトにリスクはないことを示している.
科学分野:
- 獣医ウイルス学 獣医ウイルス学
- 霊長類の健康について
- 動物性感染症の研究
背景:
- アメリカとヨーロッパでは,輸入類人猿からヒトへのフィロウイルスの感染が懸念されています.
- 猿は,エボラウイルスやレストンウイルスを含む,アフリカとアジアのフィロウイルスに対する低チーターの抗体を発現することができます.
研究 の 目的:
- 感染した非ヒト霊長類からヒトへのフィロウイルス感染のリスクを評価する.
- 低チーターのフィロウイルス抗体を持つ健康な猿が健康に危険性があるかどうかを判断する.
主な方法:
- 実験的にフィロウイルスに感染した42の非ヒト霊長類を研究した.
- ウイルスの回復とポリメラーゼ連鎖反応 (PCR) によるRNA検出は,血清と組織サンプルで実施されました.
- 血清検査は,抗体発現とクロス反応性を評価した.
主要な成果:
- フィロウイルスは,感染後最初の15日間で,霊長類のPCRで回収可能であり検出可能でした.
- ウイルスとウイルスのRNAは,挑戦から20〜600日後の生存動物では検出できませんでした.
- 感染後14〜21日,ウイルスのクリアランスと一致して,高チーターのクロス反応性抗体が開発されました.
結論:
- フィロウイルス感染を生き残った霊長類は,ウイルスを除去し,保護性抗体を形成します.
- 低チーターのフィロウイルス抗体を持つ健康なサルは,感染していないと考えられており,ヒトへの感染のリスクはありません.
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