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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

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関連する実験動画

Updated: Jul 10, 2026

Determining Optimal Cytotoxic Activity of Human Her2neu Specific CD8 T cells by Comparing the Cr51 Release Assay to the xCELLigence System
11:31

Determining Optimal Cytotoxic Activity of Human Her2neu Specific CD8 T cells by Comparing the Cr51 Release Assay to the xCELLigence System

Published on: August 8, 2012

感染症はT細胞の耐性を破る.

M Röcken1, J F Urban, E M Shevach

  • 1Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.

Nature
|September 3, 1992
PubMed
まとめ
この要約は機械生成です。

Nippostrongylus brasiliensisの感染は,Staphylococcus enterotoxin B (SEB) によって確立されたT細胞耐性を破ることができます. これは,感染症剤が,アナーギー性T細胞を活性化することによって,自己免疫疾患を誘発する可能性があることを示唆しています.

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T Cells Capture Bacteria by Transinfection from Dendritic Cells
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An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction
10:17

An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction

Published on: December 8, 2016

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Last Updated: Jul 10, 2026

Determining Optimal Cytotoxic Activity of Human Her2neu Specific CD8 T cells by Comparing the Cr51 Release Assay to the xCELLigence System
11:31

Determining Optimal Cytotoxic Activity of Human Her2neu Specific CD8 T cells by Comparing the Cr51 Release Assay to the xCELLigence System

Published on: August 8, 2012

T Cells Capture Bacteria by Transinfection from Dendritic Cells
11:39

T Cells Capture Bacteria by Transinfection from Dendritic Cells

Published on: January 13, 2016

An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction
10:17

An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction

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科学分野:

  • 免疫学 免疫学とは
  • 自己免疫とは,自己免疫である.
  • 感染症 感染症とは

背景:

  • T細胞の耐性は,クローン欠損またはアナージーによって確立され,自己免疫反応を防ぐ.
  • 自動反応性T細胞は,通常,自己耐性を維持するために抑制されます.

研究 の 目的:

  • 併発感染が確立されたT細胞耐性を破るかどうかを調査する.
  • 感染剤がT細胞耐性を回避するメカニズムを特定する.

主な方法:

  • Staphylococcus enterotoxin B (SEB) を使用したマウスにおけるT細胞耐性の誘導.
  • 耐性のあるT細胞をSEBで試験管内でテストし,サイトカインの産生 (インタールイキン-2,インタールイキン-4) を評価する.
  • 耐性のあるマウスをニポストロンギルス (Nippostrongylus brasiliensis) というネマトードに感染させ,T細胞の反応を in vivo で分析した.

主要な成果:

  • SEB耐性T細胞は,インビトロSEBチャレンジでインタールイキン-2または-4を産生しなかった.
  • SEB耐性マウスのN. brasiliensis感染は,耐性T細胞の正常な拡張につながった.
  • 感染はまた,耐性および正常な動物の両方で,SEB反応性,インタールイキン-4生成T細胞の増加をもたらしました.

結論:

  • Nippostrongylus brasiliensisの感染は,SEBが誘発したT細胞の耐性を効果的に回避する.
  • 感染症剤は,代替経路を通じて無性T細胞を活性化することで,自己免疫を誘発する可能性があります.
  • この研究は,自己免疫疾患の発症における感染性トリガーの潜在的なメカニズムを強調しています.