トラクエの血液動力学的効果は,静脈注射アドレナリンと比較した
1Department of Anaesthetics, Derriford Hospital, Plymouth, Devon, UK.
Lancet (London, England)
|October 10, 1992
まとめ
トラクエアアドレナリンは,静脈注入量より2倍の投与量であっても,心停止患者の研究で有意な血液動力学的効果を示さなかった. 蘇生中の有効性のために,より高い用量が必要になる可能性があります.
科学分野:
- 心臓病学 心臓病学
- 緊急医療 緊急医療
- 薬理学 薬理学とは
背景:
- 静脈内へのアクセスは,心肺蘇生中の薬物投与に不可欠です.
- トラクエによるアドレナリンの投与は,静脈内投与ができない場合の代替手段です.
- 現在の推奨では,静脈内投与の2倍の気管内投与量を推奨しています.
研究 の 目的:
- 低用量の気管と静脈内アドレナリンの血液動力学的効果を調査する.
- 現在の気管アドレナリン投与推奨量の有効性を評価する.
主な方法:
- ランダム化クロスオーバー研究で,股関節置換手術を受けた麻酔を受けた12人の患者が参加した.
- 患者は静脈内 (0.1マイクログラム/kg) と気管内 (0.5マイクログラム/kg) でアドレナリンを投与した.
- 静脈動脈圧と心拍数を含む血液動力学的パラメータをモニタリングしました.
主要な成果:
- 静脈内アドレナリン (0.1マイクログラム/kg) は,心拍数変化が最小で,静脈動脈圧を平均で40.5mmHg大幅に上昇させた.
- トラクエアアドレナリン (0.5マイクログラム/kg) は,動脈圧や心拍数に有意な効果を示さなかった.
- トラクエアアドレナリンの低用量は,測定可能な血液動力学的影響がない.
結論:
- アドレナリンの推奨気管用投与量 (静脈注射の2倍) は,心臓発作の治療に効果的でない可能性が高い.
- 動物の研究に基づいて,潜在的に静脈内投与量より10倍以上の高濃度の気管用投与量が必要になる可能性があります.
- 再蘇生のための効果的な気管アドレナリン投与を確立するために,さらなる研究が必要です.
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