高齢者の睡眠と覚醒の習慣の関連は,サーカディアンペースメーカーの出力の変化と関係しています

C A Czeisler¹, M Dumont, J F Duffy

¹Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115-5817.

Lancet (London, England)

|October 17, 1992

まとめ

睡眠パターンは,体内の変化により,年齢とともに変化します.

科学分野:

クロノバイオロジークロノバイオロジー
ゲロントロジーはゲロントロジーの学科です.
スリープ・メディシン (睡眠医学)

背景:

高齢者はしばしば睡眠障害を報告しますが,睡眠の必要性は年齢とともに減少しません.
睡眠のタイミングと整合の年齢に関連する変化が観察されています.
根本的なメカニズム,特に昼間ペースメーカーの変化は,調査が必要です.

研究の目的:

人間の昼夜ペースメーカーの出力における年齢関連の変化を調査する.
サーカディアンリズム振幅と相の変化が老化と相関するかどうかを評価する.
サーカディアンペースメーカーの機能と高齢者の睡眠障害との関係を調査する.

主な方法:

40時間以上持続的な覚醒状態で継続的に体温を測定する.
恒常的な行動および環境条件が維持された.
若年成人と高齢者の間の内生昼間気温振動 (ECA) 段階と振幅の比較.

主要な成果:

平均的なECA振幅は,若年成人と比較して,高齢者では40%低かった.
年配の個人は,約2時間ほど早く生体内生性の気温振動 (ECP) の初期段階を示した.
習慣的な覚醒時間とECPの間の相関の精度は,年齢とともに,特に女性において低下することが示されました.

結論:

ヒトの昼夜ペースメーカーの出力における年齢に関連した体系的な変化が特定されました.
これらの昼夜変化は,高齢者が報告する一般的な睡眠障害に寄与する可能性があります.
これらの変化と日中リズムを調節する下垂体核の年齢関連の悪化との潜在的な関連.

キーワード:

NASAの規律規制生理学規律生理学非NASAのセンターです.

さらに関連する動画

07:40

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

05:59

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster

Published on: October 20, 2023

関連する概念動画

01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:

01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

01:11

Understanding Sleep

Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...

01:22

Stages of Sleep

Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...

関連する実験動画