ヘリコバクター・パイロリが人間の糞便から分離された
J E Thomas1, G R Gibson, M K Darboe
1MRC Dunn Nutrition Centre, Cambridge, UK.
Lancet (London, England)
|November 14, 1992
まとめ
研究者らは,ヒトの糞便で生存可能なヘリコバクター・パイロリを特定し,この一般的な感染症の糞口伝播経路を示唆した. この発見は,H. pyloriが地域社会で広がっていることを理解するために極めて重要です.
科学分野:
- 微生物学 微生物学とは
- 感染症 感染症は感染症です.
- 胃腸内科 胃腸内科
背景:
- ヘリコバクター・ピロリ菌は,世界中で最も一般的な慢性細菌感染症です.
- H. pylori の感染経路は,ほとんど不明のままである.
- 感染の伝播を理解することは,H. pyloriの感染を制御する鍵です.
研究 の 目的:
- ヘリコバクター・パイロリ菌の経口伝播経路の可能性を調査する.
- ガンビアの糞便サンプルからH. pyloriを分離し,特徴づけること.
- 小児におけるH. pyloriの有病率を,その有病率が高い地域における有病率を決定する.
主な方法:
- 選択媒介と遠心分離を用いて,便サンプルから生存可能なH. pyloriを分離する.
- 成長,形質,酵素活性,タンパク質プロファイルに基づく単離物の特徴化.
- 胃菌株と比較した単離物の抗原および電泳分析.
主要な成果:
- 活性の高いH. pyloriは,感染した個人の糞便から成功裏に分離されました.
- 孤立したH. pylori菌株は,典型的な胃分離体と同様の特徴を示した.
- H. pyloriは,ガンビアの村の23人の子供 (3〜27ヶ月) のうち9人の子供から分離されました.
結論:
- 便口伝播はヘリコバクター・パイロリ菌が広がる可能性が高い経路です.
- この発見は,高い流行率のコミュニティにおける糞口伝播の重要性を支持しています.
- 衛生と衛生上の介入に関するさらなる研究が正当化されるかもしれません.
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