心臓の毒性は,偶然のハーブ誘発のアコニット中毒によるものです
Lancet (London, England)
|November 21, 1992
まとめ
アコニタム植物からのアコニットアルカロイドは重度の中毒を引き起こし,致命的な心臓リズム障害につながります. これは,これらの有毒な化合物を含む伝統的なハーブ製薬の厳格な安全性モニタリングの緊急の必要性を強調しています.
科学分野:
- 毒理学 毒理学 毒理学
- 薬理学 薬理学とは
- ハーブリン薬は,ハーブリン薬です.
背景:
- アコニチンとアコニタム植物からの関連アルカロイドは強力な心臓毒素です.
- これらの有毒なアルカロイドは,伝統的な中国のハーブレシピに含まれています.
- 現代の西洋医学は,アコニットアルカロイドの治療用途を認めていない.
研究 の 目的:
- 草原誘発のアクニット中毒による事故による生命を脅かす中毒の症例を記録し,分析する.
- 観察された有毒効果に起因する因果要因を特定する.
- 狭い安全限界を持つ植物性物質の安全性監視の重要性を強調する.
主な方法:
- 17人の中国人被験者がアコニットに毒をつけられたと疑われるケースのドキュメント.
- 症状の発生と進行の臨床観察.
- 致病剤を特定するための毒理学的評価.
主要な成果:
- 17人の患者全員が,薬草物質を摂取した2時間以内に,アコニット毒性の症状を示した.
- 患者の大半は,心室動脈不全と動を含む重度のタキアリズムを発症した.
- 2人の患者は,アコニットアルカロイドの心臓毒性作用により死亡しました.
結論:
- アコニタムの根茎を誤って摂取すると,重症で生命を脅かすアコニット中毒を引き起こす可能性があります.
- アコニットアルカロイドは,これらの重度の毒性イベントの主な原因です.
- アコナイトのような有毒化合物を含有するハーブ製品の厳格な監視は,公衆の安全のために不可欠です.
さらに関連する動画
11:14Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
Published on: October 2, 2016
09:16Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method
Published on: May 12, 2023
関連する概念動画
01:14Prevention of Further Absorption of Poison
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
01:26Anticholinesterase Agents: Poisoning and Treatment
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
01:00Drug Toxicity: Overview
Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
01:30Toxidromes: Clinical Features
Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
01:26Pharmaceutical Poisoning: Potential Scenarios
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
01:26Pharmaceutical Poisoning: Treatment Strategies
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...