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関連する概念動画

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

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Anti-Nuclear Antibody Screening Using HEp-2 Cells
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Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 24, 2014

結核 (TB) について

Thomas R Frieden1, Timothy R Sterling, Sonal S Munsiff

  • 1New York City Department of Health and Mental Hygiene, New York, NY 10013, USA. tfrieden@health.nyc.gov

Lancet (London, England)
|September 19, 2003
PubMed
まとめ
この要約は機械生成です。

結核は,特に発展途上国において,世界の主要な殺人者であり続けています. 改善された診断,DOTSのような治療戦略,そして将来のワクチンは,コントロールに不可欠です.

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13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 24, 2014

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Nuclei Isolation from Adult Mouse Kidney for Single-Nucleus RNA-Sequencing

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科学分野:

  • 公衆衛生は公衆衛生である.
  • 感染症 感染症は感染症です.
  • グローバル・ヘルス グローバル・ヘルス

背景:

  • 結核 (TB) は,世界で2番目に多い死因であり,毎年約200万人の死因となっている.
  • HIVが原因でアフリカで,社会経済的要因と医療の減少により旧ソ連で発生率が上昇しています.
  • 診断はMycobacterium tuberculosisの培養に依拠しているが,迅速な唾液抹跡検査と分子方法が不可欠である.

研究 の 目的:

  • 世界中で結核対策の現状を見直す.
  • 診断,治療,予防戦略における課題と進歩を強調する.
  • ワクチンの開発と治療システムの継続的な努力の必要性を強調する.

主な方法:

  • 世界的な結核の発生率,死亡率,治療データのレビュー.
  • 培養物,唾液抹跡,分子方法を含む診断技術の分析.
  • 治療戦略の評価,直接観察された治療,短期間 (DOTS) アプローチに焦点を当てた.

主要な成果:

  • 治癒率の95%以上は,複数の薬剤を併用した6ヶ月の治療法で達成可能である.
  • 直接観察された短期治療 (DOTS) は標準的な治療法ですが,世界の症例の3分の1しか治療を受けていません.
  • 過去10年間,診断と治療の分野で大きな進歩がみられたが,世界の目標は依然として達成されていない.

結論:

  • 効果的な結核対策には,体系的なモニタリング,症例検出の改善,およびDOTSの広範な採用が必要です.
  • 新しいワクチンが開発中ですが,今後数十年にわたって改善された治療システムは不可欠です.
  • 世界的に結核を抑制することは,開発途上国への結核の影響を軽減し,先進国におけるリスクを軽減するために不可欠です.